New Orleans is the most powerful Caster city in the country with the greatest convergence of Dark and Light power in modern times. It is a place where anything can happen, at any hour of the day, as stated by John Breed in Beautiful Redemption.
When Silas' father broke Silas and Arelia up, she fled to New Orleans with Leah Ann and Twyla also lived in New Orleans. Amma went to through to the Tunnels to New Orleans to make a deal with a bokor to change the cards in Beautiful Chaos. Abraham owned a bar, former speakeasy, for Incubuses called 'Dark Side o' the Moon'. Lena and John went to New Orleans to get the Book of Moons from Abraham and rescued Ridley who was trapped in a cage in Beautiful Redemption.